Fulminant Cryptosporidiosis Associated with Digestive
نویسندگان
چکیده
3 We demonstrated recently that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal 4 adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain and other 5 Cryptosporidium species to induce digestive neoplasia in dexamethasone-treated SCID mice was 6 explored. SCID mice infected with C. parvum TUM1 developed a fulminant cryptosporidiosis 7 associated with intramucosal adenocarcinoma, which is considered an early histological sign of 8 invasive cancer. Both, evidence of a role of C. parvum in adenocarcinoma induction and the 9 extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum induced 10 gastro-intestinal cancer in humans should be assessed. 11
منابع مشابه
Opportunistic digestive parasitic infections in adults infected with HIV: epidemiological expression
Results Among the 70 patients involved, the average age was 37 years with a slight male predominance. The median CD4 was 62cel/mm 3. Digestive opportunistic parasitic were indicative of HIV infection in 54 cases (77%) and in 16 cases (23%) they occurred at the waning of treatment failure. All patients had diarrhea. These opportunistic parasitic agents were isolated only in 56 cases: the cryptos...
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BACKGROUND Cryptosporidiosis has been shown to be a common cause of diarrhoea in both immunocompetent and immunosuppressed individuals. There are very few data on the distribution of Cryptosporidium parvum along the gastrointestinal tract. AIMS To evaluate the location of Cryptosporidium parasites in the digestive tract of patients with AIDS. METHODS Gastrointestinal localisation of C parvu...
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